cystic fibrosis

noun

: a common, progressive hereditary disease of exocrine gland function that typically appears in infancy or early childhood and is marked by the accumulation of thick, sticky mucus in the ducts and passages of various organs and especially those of the lungs and pancreas resulting in shortness of breath, persistent cough, chronic respiratory infection, pancreatic enzyme insufficiency, faulty digestion, malnutrition, and poor growth

Note: The genetic mutation linked to cystic fibrosis causes disruption in the movement of chloride ions and water across cell membranes resulting in mucus that is thick and sticky instead of thin and slippery and in elevated concentrations of sodium and chloride in sweat and saliva. Cystic fibrosis occurs especially in people of northern European ancestry and is inherited as an autosomal recessive trait requiring that both parents pass on a copy of the defective gene on a chromosome other than a sex chromosome.

… children with cystic fibrosis are born with healthy lungs; only later do their lungs become plugged with mucus and incur infections.The Journal of the American Medical Association
Cystic fibrosis is the most common lethal inherited disorder in the United States. Approximately 30,000 people in this country have inherited two defective copies of the CF gene and thus the disease; approximately 1 in 20 Americans has just one copy of the gene and is a carrier of the disease.Joe Palca
abbreviation CF

Examples of cystic fibrosis in a Sentence

Recent Examples on the Web The pathogen can be deadly to people with underlying conditions such as cystic fibrosis, a genetic disorder that impairs the cells’ ability to effectively flush mucus from the lungs and other body systems. Corinne Purtill, Los Angeles Times, 7 May 2024 In general, the caloric needs of a child with cystic fibrosis depend on their age, weight, severity of disease and other factors, according to the Academy of Nutrition and Dietetics. Mary Kekatos, ABC News, 7 May 2024 The company’s overall revenue guidance remains unchanged, with Vertex expecting between $10.55 billion to $10.75 billion this year, much of which will be driven by sales of its cystic fibrosis drug Trikafta, which brought in $2.48 billion during the first quarter. Elaine Chen Reprints, STAT, 7 May 2024 Fadi, who has cystic fibrosis and weighs about 25 pounds, is suffering from severe malnourishment caused by famine, according to the Palestine Children’s Relief Fund, which coordinated the children’s journeys with assistance from the World Health Organization. Ana Ley, New York Times, 5 May 2024 The firm is deeply involved in development and manufacturing of crucial therapies for cancer, cystic fibrosis, H.I.V. and other illnesses. Christina Jewett, New York Times, 15 Apr. 2024 This could reduce the prevalence of many hereditary diseases like muscular dystrophy or cystic fibrosis. Bernard Marr, Forbes, 12 Feb. 2024 For instance, the cystic fibrosis treatment Trikafta (Vertex Pharmaceuticals) went up 5.9 percent to $26,546 for a 28-day supply. Beth Mole, Ars Technica, 19 Jan. 2024 Some notable discoveries during this period include the identification of the gene responsible for sickle cell anemia and the gene linked to cystic fibrosis. William A. Haseltine, Forbes, 27 Mar. 2024

These examples are programmatically compiled from various online sources to illustrate current usage of the word 'cystic fibrosis.' Any opinions expressed in the examples do not represent those of Merriam-Webster or its editors. Send us feedback about these examples.

Word History

First Known Use

1938, in the meaning defined above

Time Traveler
The first known use of cystic fibrosis was in 1938

Dictionary Entries Near cystic fibrosis

Cite this Entry

“Cystic fibrosis.” Merriam-Webster.com Dictionary, Merriam-Webster, https://www.merriam-webster.com/dictionary/cystic%20fibrosis. Accessed 14 May. 2024.

Kids Definition

cystic fibrosis

noun
: an inherited disease marked by the buildup of thick sticky mucus chiefly in the lungs and pancreas leading to recurrent lung infections and digestive problems

Medical Definition

cystic fibrosis

noun
: a common, progressive, hereditary disease of exocrine gland function that typically appears in infancy or early childhood and is marked by the accumulation of thick, sticky mucus in the ducts and passages of various organs and especially those of the lungs and pancreas resulting in shortness of breath, persistent cough, chronic respiratory infection, pancreatic enzyme insufficiency, faulty digestion, malnutrition, and poor growth

Note: The genetic mutation linked to cystic fibrosis causes disruption in the movement of chloride ions and water across cell membranes resulting in mucus that is thick and sticky instead of thin and slippery and in elevated concentrations of sodium and chloride in sweat and saliva. Cystic fibrosis occurs especially in people of northern European ancestry and is inherited as an autosomal recessive trait requiring that both parents pass on a copy of the defective gene on a chromosome other than a sex chromosome.

called also fibrocystic disease of the pancreas, mucoviscidosis

abbreviation CF

More from Merriam-Webster on cystic fibrosis

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